Glycosphingolipids: structure and function
نویسندگان
چکیده
منابع مشابه
Glycosphingolipids: structure and function
Glycosphingolipids occur in most hi her organisms as 200 compounds in this class have been isolated and chemically characterized. In this aper, we compare the structures of several complex glycosphingoEpids and discuss the utilit of fast atom bombardment mass spectrometry in the MSldS mode with collision-assisted dissociation of the ceramide ion to study details of the ceramide structure. The f...
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Glycosphingolipids (GSLs) constitute major components of enterocytes and were hypothesized to be potentially important for intestinal epithelial polarization. The enzyme UDP-glucose ceramide glucosyltransferase (Ugcg) catalyzes the initial step of GSL biosynthesis. Newborn and adult mice with enterocyte-specific genetic deletion of the gene Ugcg were generated. In newborn mutants lacking GSLs a...
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The emphasis laid by glycobiologists on cell adhesion in terms of carbohydrate interaction is now shifted to the aspects where the interaction is associated with the regulation of various cellular activities via biosignalling and glycosphingolipids, in particular, gangliosides (sialic acid-containing glycosphingolipids) play an important functional role. The significance of the carbohydrate-pro...
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ژورنال
عنوان ژورنال: Pure and Applied Chemistry
سال: 1989
ISSN: 1365-3075,0033-4545
DOI: 10.1351/pac198961071307